S44 Lung clearance index (LCI) and FEV1 correlate equally with treatment burden as measured by cystic fibrosis questionnaire-revised (CFQ-R)
نویسندگان
چکیده
منابع مشابه
Lung clearance index in adults with non-cystic fibrosis bronchiectasis
BACKGROUND Lung clearance index (LCI) is a measure of abnormal ventilation distribution derived from the multiple breath inert gas washout (MBW) technique. We aimed to determine the clinical utility of LCI in non-CF bronchiectasis, and to assess two novel MBW parameters that distinguish between increases in LCI due to specific ventilation inequality (LCIvent) and increased respiratory dead spac...
متن کاملLung clearance index predicts pulmonary exacerbations in young patients with cystic fibrosis.
RATIONALE The lung clearance index (LCI) is a promising endpoint for use in cystic fibrosis (CF) clinical trials, but correlations with validated clinical endpoints have not yet been established. OBJECTIVE This study aimed to demonstrate that, in young patients with CF, baseline LCI predicts subsequent pulmonary exacerbation (PE) and correlates with the respiratory domain of the CF Questionna...
متن کاملLung clearance index at 4 years predicts subsequent lung function in children with cystic fibrosis.
RATIONALE The markedly improved life expectancy of children with cystic fibrosis (CF) has created a new challenge, as traditional markers of lung disease are frequently normal in young children. This prevents identification of individuals who may benefit from more aggressive therapy and also obliges large study numbers and prolonged duration for intervention studies. There is an urgent need for...
متن کاملIs Lung Clearance Index (LCI) Affected by the Severity of Lung Disease in CF?
Background: LCI has been proven an effective tool in the detection of lung disease in CF. Objectives: a) To assess the correlation of ventilation inhomogeneity indices with structural damages of the lung, among different groups of disease severity and b) To compare the associations among MBW parameters with spirometry and CT. Method: Forty-four children and adolescents with CF participated in t...
متن کاملFEV1 decline in cystic fibrosis.
I read the paper by Taylor-Robinson et al with interest with regard to modelling the decline in forced expiratory volume in 1 second (FEV1) in patients with cystic fibrosis (CF). The authors have made the assumption that expressing spirometry results as a per cent of predicted (PP) is a valid way to use lung function over a wide age range. Young adult patients with cystic fibrosis die with abso...
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ژورنال
عنوان ژورنال: Thorax
سال: 2011
ISSN: 0040-6376
DOI: 10.1136/thoraxjnl-2011-201054b.44